An invitation to reunite with her estranged Oglala Lakota family launches a grieving young woman (Lily Gladstone) on an unexpected road trip from the Midwest toward the Texas-Mexico border. In this largely solitary journey with an unknown destination Tana navigates the complex post-2016 election social climate and a natural landscape that is increasingly surreal. Along the way she bonds with unexpected people that are as much a part of the landscape as the mountains and roads. At times at ease at times on edge as a woman traveling alone familiar faces and strangers shape her journey as she grapples with the pain of her recent loss and seeks to understand her place in the world.