Worn down and out of luck aging publisher Will Randall (Jack Nicholson) is at the end of his rope when a younger co-worker snatches his job out from under his nose. But after being bitten by a wolf Will suddenly finds himself energized more competitive than ever and possessed with amazingly heightened senses. Meanwhile the beautiful daughter of his shrewd boss begins to fall for him - without realizing that the man she's begun to love is gradually turning into the creature by which he was bitten.