Mankind discover the existence of the Vampire and Lycan species and begin a war to annihilate the races. When Selene meets with Michael they're hit by a grenade. 12 years later Selene awakens and meets the vampire David. She learns she had been the subject of scientist Dr. Jacob Lane and the Vampire and Lycan species have been practically eradicated from Earth. Now Selene and David must protect a 12-year-old girl against the Lycans who intend to use her.