As a young girl Alicia "Ace" Anderson (Swain) had been taught the fine art and the mathematical probabilities of Texas Hold-em poker by the father she adored. But that world came to an end when her father was taken from her in a fatal auto accident. Years later as she enters medical school she will need to call upon the skills her father taught her as she struggles with the rigorous medical training mounting financial pressures and the seamier side of medicine. Her friends and fellow students combine their unique talents and skills to produce a team who may well be the ultimate poker machine. But as the stakes in both the casinos and the operating room continue to rise Ace comes to understand what her father taught her: in order to really live you need to go all in.